Betty Blight is Doctor Blight's grandmother. She appears in Hog Tide, an episode that is set in the 40's. She works alongside Hoggish Greedly's grandfather, Don Porkaloin, indicating perhaps that the two families have a long history together. During the episode Hog Tide she creates the "Moon Manipulator" - a machine that can control the weather. She uses it to change the path of a hurricane and bring it ashore.
Betty works as a singer in hotels to make money, but her main interest is in science.